Quantitative Structure–Cytotoxicity Relationship of 2-Styrylchromones
نویسندگان
چکیده
منابع مشابه
Quantitative structure-cytotoxicity relationship of 3-styrylchromones.
BACKGROUND Fifteen 3-styrylchromones were subjected to quantitative structure-activity relationship (QSAR) analysis based on their cytotoxicity, tumor selectivity and anti-HIV activity, in order to explore their biological activities. MATERIALS AND METHODS Cytotoxicity against four human oral squamous cell carcinoma (OSCC) cell lines and three human oral normal cells was determined by the 3-(...
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2-Styrylchromones (2-SC) are a chemical family of oxygen heterocyclic compounds, vinylogues of flavones (2-phenylchromones), whose occurrence in nature has been reported. Recently, several 2-SC derivatives were demonstrated to have antioxidant properties, namely, xanthine oxidase inhibition, hepatoprotection against pro-oxidant agents in cellular and non-cellular systems and scavenging activity...
متن کاملQuantitative Structure-Cytotoxicity Relationship of 2-Azolylchromones.
BACKGROUND/AIM Twenty-four 2-azolylchromones were subjected to quantitative structure-activity relationship (QSAR) analysis based on their cytotoxicity and tumor specificity, in order to find their new biological activities. MATERIALS AND METHODS Cytotoxicity against two human oral squamous cell carcinoma cell lines and two human normal oral mesenchymal cells was determined by the 3-(4,5-dime...
متن کاملInhibition of NF-kB activation and cytokines production in THP-1 monocytes by 2-styrylchromones.
Nuclear factor kappa B (NF-kB) is one of the most important transcription factors whose modulation triggers a cascade of signaling events, namely the expression of many cytokines, enzymes, chemokines, and adhesion molecules, some of which being potential key targets for intervention in the treatment of inflammatory conditions. The 2-styrylchromones (2-SC) designation represents a well-recognize...
متن کاملSynthesis and evaluation of antirhinovirus activity of 3-hydroxy and 3-methoxy 2-styrylchromones.
Recently, we identified 2-styrylchromones as a new class of antirhinovirus flavonoids with moderate activity against both rhinovirus groups A and B. In order to improve the antiviral effect of the first series of tested 2-styrylchromones, a hydroxy or methoxy group was introduced in position 3 of the chromone ring. Cytotoxicity and antiviral activity of the new synthesized compounds were evalua...
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ژورنال
عنوان ژورنال: Anticancer Research
سال: 2019
ISSN: 0250-7005,1791-7530
DOI: 10.21873/anticanres.13863